All Clinical Trials
Official Title A Phase III Study of Entecavir vs Lamivudine in Adults With Chronic Hepatitis B Infection and Negative for Hepatitis B e Antigen
Phase Phase III
ClinicalTrials.gov NCT00035789
Treatments
Entecavir
, Entecavir
Tradename:BaracludeOther Names:ETVClass:Oral Antivirals (Nucleos(t)ide Analogues)Lamivudine
Lamivudine
Tradename:Epivir HBVOther Names:3TCClass:Oral Antivirals (Nucleos(t)ide Analogues)Funding
IndustryBristol-Meyers Squibb
References
- Lai CL, Shouval D, Lok AS, et al. Entecavir versus lamivudine for patients with HBeAg-negative chronic hepatitis B. N Engl J Med. 2006;354:1011-20.
Official Title A Phase III Study of Entecavir vs Lamivudine in Adults With Chronic Hepatitis B Infection and Positive for Hepatitis B E Antigen
Phase Phase III
ClinicalTrials.gov NCT00035633
Treatments
Entecavir
, Entecavir
Tradename:BaracludeOther Names:ETVClass:Oral Antivirals (Nucleos(t)ide Analogues)Lamivudine
Lamivudine
Tradename:Epivir HBVOther Names:3TCClass:Oral Antivirals (Nucleos(t)ide Analogues)Funding
IndustryBristol-Meyers Squibb
References
- Chang TT, Gish RG, de Man R, et al. A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B. N Engl J Med. 2006;354:1001-10.
- Gish RG, Lok AS, Chang TT, et al. Entecavir therapy for up to 96 weeks in patients with HBeAg-positive chronic hepatitis B. Gastroenterology. 2007;133:1437-44.
Official Title A Randomized, Double Blind Trial of LdT (Telbivudine) Versus Lamivudine in Adults With Compensated Chronic Hepatitis B
Phase Phase III
ClinicalTrials.gov NCT00057265
Treatments
Lamivudine
Lamivudine
Tradename:Epivir HBVOther Names:3TCClass:Oral Antivirals (Nucleos(t)ide Analogues)Funding
IndustryNovartis
References
- Lai CL, Gane E, Liaw YF, et al. Telbivudine versus lamivudine in patients with chronic hepatitis B. N Engl J Med. 2007;357:2576-88.
Official Title Peginterferon alfa-2a alone, lamivudine alone, and the two in combination in patients with HBeAg-negative chronic hepatitis
Treatments
Lamivudine
, Lamivudine
Tradename:Epivir HBVOther Names:3TCClass:Oral Antivirals (Nucleos(t)ide Analogues)Peginterferon alfa-2a
Peginterferon alfa-2a
Tradename:PegasysClass:Immune Modulators (Interferons)Funding
IndustryRoche
References
- Marcellin P, Bonino F, Lau GK, et al. Sustained response of hepatitis B e antigen-negative patients 3 years after treatment with peginterferon alpha-2a. Gastroenterology. 2009;136:2169-79.
- Marcellin P, Lau GK, Bonino F, et al. Peginterferon alfa-2a alone, lamivudine alone, and the two in combination in patients with HBeAg-negative chronic hepatitis B. N Engl J Med. 2004;351:1206-17.
Official Title Peginterferon Alfa-2a, Lamivudine, and the Combination for HBeAg-Positive Chronic Hepatitis B
Phase Phase III
Treatments
Lamivudine
, Lamivudine
Tradename:Epivir HBVOther Names:3TCClass:Oral Antivirals (Nucleos(t)ide Analogues)Peginterferon alfa-2a
Peginterferon alfa-2a
Tradename:PegasysClass:Immune Modulators (Interferons)Funding
IndustryRoche
References
- Lau GK, Piratvisuth T, Luo KX, et al. Peginterferon Alfa-2a, lamivudine, and the combination for HBeAg-positive chronic hepatitis B. N Engl J Med. 2005;352:2682-95.